[abstract] HYPERBARIC OXYGEN TREATMENT TIMING OF CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS IN RATS

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[abstract] HYPERBARIC OXYGEN TREATMENT TIMING OF CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS IN RATS

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Title: [abstract] HYPERBARIC OXYGEN TREATMENT TIMING OF CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS IN RATS
Author: Korkmaz, A; Oztas, E; Oter, S; Topal, T; Sadyr, S
Abstract: INTRODUCTION: The aim of this study was to evaluate the prophylactic potential of hyperbaric oxygenation treatment and the timing of hyperbaric oxygen (HBO2) therapy for cyclophosphamide-(CYP) induced cystitis in rats. METHODS: Forty male Sprague-Dawley rats were divided into 5 groups. Four groups received a single dose of CYP (100 mg/kg.) intraperitoneally (i.p.) at the same time (group 1 served as the control). Group 2 received CYP only; group 3 received HBO2 treatment (2.8 atmospheres absolute, 90 minutes, twice daily) before and the day after CYP. Group 4 received HBO2 before and on the day of CYP administration. Group 5 received HBO2 on the day of and the day after CYP. RESULTS: CYP injection resulted in severe cystitis. Prophylactic HBO2 treatment did not prevent the severe cystitis. After CYP injection, HBO2 treatment attenuated CYP-induced hemorrhagic cystitis in rats. CONCLUSION: Hyperbaric oxygen has a beneficial effect on repairing and healing bladder damage, though it does not function to prevent CYP-induced hemorrhagic cystitis.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1596
Date: 2003

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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