[abstract] Efficacy of hyperbaric oxygen therapy in radiation induced late side effects

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[abstract] Efficacy of hyperbaric oxygen therapy in radiation induced late side effects

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Title: [abstract] Efficacy of hyperbaric oxygen therapy in radiation induced late side effects
Author: Lieber, M; Elsaleh, H; Bui, J
Abstract: Purpose: We investigated the efficacy of Hyperbaric Oxygen Therapy (HBOT) in the management of patients with radiation induced late side effects, the majority of who had failed previous interventions. Methods and Materials: Of 105 eligible subjects, 30 had either died or were not contactable, leaving 75 who qualified for inclusion in this retrospective study. Patients answered a questionnaire documenting symptom severity before and after treatment (using Radiation Therapy Oncology Group criteria), duration of improvement, relapse incidence and HBOT-related complications. Results: The rate of participation was 60percent (45/75). Improvement of principal presenting symptoms after HBOT was noted in 75percent of Head and Neck (H and N), 100percent of pelvic and 57percent of "other" subjects (median duration of response of 62, 72 and 68 weeks, respectively). Bone and bladder symptoms were most likely to benefit from HBOT (response rate 81percent and 83percent, respectively). Fifty percent of subjects with soft tissue necrosis/mucous membrane side effects improved with HBOT. The low response rate of salivary (11percent), neurological (17percent), laryngeal (17percent) and upper gastro-intestinal (GI) symptoms (22percent) indicate that these were more resistant to HBOT. Relapse incidence was low (22percent) and minor HBOT-related complications occurred in 31percent of patients. Conclusion: HBOT is a safe and effective treatment modality offering durable relief in the management of radiation induced bone lesions either by itself or as an adjunct treatment. Radiation soft tissue necrosis, cystitis and proctitis also appeared to benefit from HBOT but the present study did not have sufficient numbers to reliably predict long-term response.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1578
Date: 2004

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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