[abstract] MAJOR CLINICAL IMPROVEMENT AND PROMINENT INCREASE IN LOWER EXTREMITY DISTAL TRANSDERMAL OXYGEN TENSIONS IN A CASE OF THROMBOANGIITIS OBLITERANS TREATED WITH HYPERBARIC OXYGEN THERAPY

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[abstract] MAJOR CLINICAL IMPROVEMENT AND PROMINENT INCREASE IN LOWER EXTREMITY DISTAL TRANSDERMAL OXYGEN TENSIONS IN A CASE OF THROMBOANGIITIS OBLITERANS TREATED WITH HYPERBARIC OXYGEN THERAPY

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Title: [abstract] MAJOR CLINICAL IMPROVEMENT AND PROMINENT INCREASE IN LOWER EXTREMITY DISTAL TRANSDERMAL OXYGEN TENSIONS IN A CASE OF THROMBOANGIITIS OBLITERANS TREATED WITH HYPERBARIC OXYGEN THERAPY
Author: Ortiz, JD; Hindsley, BW; Hodgson, RJ; Pisarello, JB
Abstract: INTRODUCTION: Thromboangiitis obliterans (Buerger's Disease) is a nonatherosclerotic segmental inflammatory disease of the small and medium-sized arteries of the arms and legs and is associated with the use of tobacco. The only proven strategy to prevent progression of the disease and avoid amputation is the complete discontinuation of cigarette smoking. MATERIALS AND METHODS: A 41-year-old male with a greater than 20-pack-year smoking history and a 10 year history of progressive cold intolerance of the distal extremities, foot claudication and recent toe ulceration. An extensive laboratory investigation was unremarkable. Transthoracic and transesophageal echocardiography failed to identify cardiac source of emboli. Arteriography of both lower extremities and right upper extremity demonstrated multiple small vessel disease in both feet and in the right hand. The patient underwent 19 daily HBO treatments at 2ATA for 60 minutes over a period of one month. Transdermal oxygen levels (TCPO2) of the upper and lower distal extremities were measured before and after HBO. RESULTS: The patient showed marked clinical improvement of the lower extremity claudication, toe ulcer and complete resolution of symptomatology in both upper extremities. Average hand and feet TCPO2 rose from 18.75+/-10.94 to 26.75+/-6.34 (mmHg, mean+/-sd) (p=0.14) and 8.0+/-9.4 to 26.0+/-10.8 mmHg (p less than 0.001), respectively, before and after HBO. CONCLUSIONS: angiogenesis appears to be the most likely mechanism underlying the significant clinical improvement of distal extremity ischemic symptoms in this patient with Buerger's Disease treated with HBO. Buerger's Disease, Thromboangiitis obliterans
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1199
Date: 2002

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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