[abstract] MAGNESIUM AND POTASSIUM DEFICIENCY MIGHT EXACERBATE HYPERBARIC OXYGEN INDUCED CNS TOXICITY

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[abstract] MAGNESIUM AND POTASSIUM DEFICIENCY MIGHT EXACERBATE HYPERBARIC OXYGEN INDUCED CNS TOXICITY

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Title: [abstract] MAGNESIUM AND POTASSIUM DEFICIENCY MIGHT EXACERBATE HYPERBARIC OXYGEN INDUCED CNS TOXICITY
Author: Wang, S
Abstract: BACKGROUND: A 66 y/o woman got a generalized convulsion after exposure to hyperbaric oxygen (HBO, 60 feet) for 30 minutes. The convulsion last 5 minutes and subsided soon after moving out. Consciousness recovered in 5 minutes with no complication observed thereafter. The patient had smoothly received the HBO therapy (60 feet x 60 minutes) thrice and had no history of seizure, brain injury or stroke in the past. She was diabetic and her indication for the HBO therapy was due to osteomyelitis. Her serum glucose, sodium and calcium remained normal before and after the convulsion. The serum CPK, arterial gas and electroencephalogram were normal after the convulsion. Magnesium (Mg) and potassium (K) were the only two abnormal parameters detectable throughout the course. Her serum Mg was 1.2 mmol/L after the convulsion. The K was 2.74 mmol/L and 2.70 mmol/L before and after the convulsion, respectively. Both ions were given by supplement and returned to normal in 2 days. CONCLUSION: This case report provides evidence that Mg and K deficiency might exacerbate the HBO induced CNS toxicity. Administration of Mg salts has been shown to suppress HBO induced CNS toxicity in rats and been suggested to treat oxygen toxicity. This report records the clinical finding that hypomagnesemia is associated with HBO induced CNS toxicity in humans. Mg is closely related to K regulation. Half of patients with Mg deficiency become hypokalemic. Also, the hypokalemia, refractory to K supplements, is often due to Mg deficiency. In summary, either hypomagnesemia alone or the coexisting hypomagnesemia and hypokalemia might have exacerbated the HBO induced CNS oxygen toxicity.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1108
Date: 2002

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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