[abstract]A BLINDED TRIAL TO INVESTIGATE IF ‘PRESSURE-FAMILIAR’ INDIVIDUALS CAN DETERMINE CHAMBER PRESSURE

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[abstract]A BLINDED TRIAL TO INVESTIGATE IF ‘PRESSURE-FAMILIAR’ INDIVIDUALS CAN DETERMINE CHAMBER PRESSURE

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Title: [abstract]A BLINDED TRIAL TO INVESTIGATE IF ‘PRESSURE-FAMILIAR’ INDIVIDUALS CAN DETERMINE CHAMBER PRESSURE
Author: Weaver LK; Churchill S; Bell J; Deru K; Snow GL
Abstract: Introduction/Background: Using different chamber pressures is a method to blind participants in hyperbaric clinical trials. We conducted a prospective study to determine if divers or hyperbaric chamber attendants could discern chamber pressure; important to determine eligibility for hyperbaric studies. Materials and methods: We exposed experienced divers and chamber attendants to HBO2 (100 percent O2 -1.5 atmospheres absolute-atm abs) or sham (air -1.2 atm abs) randomized by group (by appointment time) to one of four pressures, 1.2 or 1.5 atm abs from sea level and 6,000 feet altitude. Following the pressure excursions, participants estimated their “depth” in feet of sea water (fsw). Results: Forty-two volunteers signed informed consent: 10 females and 32 males, ages 46±10 years (mean±1 SD), dive experience 366±562 dives. Four were hyperbaric chamber attendants. When estimating depth exposure, 19/42 (45 percent) selected “I do not know.” Three of 23 (13 percent) were within 2 fsw of the actual depth (correlation between actual depth and estimate -0.0067) (p=0.9758). Two underestimated their depth. We found no indication of cluster randomization effect (p=0.155). Summary/Conclusions: The results suggest that experienced divers cannot discriminate chamber pressures of 1.2 and 1.5 atm abs, and therefore could be included in hyperbaric clinical trials using this dosing without compromising the masking integrity.
Description: Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/10540
Date: 2012

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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